Modifying Effect of Vitamin E on Adriamycin and Cyclophosphamide Induced Genotoxicity and Antioxidant Status in Rats
نویسنده
چکیده
In the present study, we have evaluated the protective effect of vitamin E (VE) against adriamycin (AD) and cyclophosphamide (CP) induced genotoxicity using chromosome aberration and micronucleus assays in Wistar rat bone marrow cells. The level of lipid peroxidation product malondialdehyde, the activity of antioxidant enzymes
منابع مشابه
Antioxidant effects of Spirulina platensis (Arthrospira platensis) on cyclophosphamide-induced testicular injury in rats
Cyclophosphamide (CP) is known to reduce fertility. The protective effects of Spirulina plantesis (SP) against CP-induced testicular toxicity were investigated. Male Wistar rats were categorized into eight groups (n = 7). Four groups of rats were administered CP at a dose of 5 mg in 5 mL distilled water kg-1 per day orally. Two of these groups were received SP (500 and 1000 ...
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Introduction and Objective: liver is an important body organ without which life is impossible. Cyclophosphamide is an alkylating agent widely used as an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. The present study aimed to find a suitable antioxidant and examine the effect of vitamin E and selenium on reducing the side effects of cyclophosphamide on liver as a vit...
متن کاملThe Effect of Vitamin E and Selenium on Cyclophosphamide Detoxification in Hepatic Tissues of Mature Rats
Introduction and Objective: liver is an important body organ without which life is impossible. Cyclophosphamide is an alkylating agent widely used as an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. The present study aimed to find a suitable antioxidant and examine the effect of vitamin E and selenium on reducing the side effects of cyclophosphamide on liver as a vit...
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